TRPC7 Antibody, Clone N64A/36: PerCP

Mouse Anti-Human TrpC7 Monoclonal IgG1

Target: TRPC7

Conjugate: PerCP

Product Type: Monoclonal

Clone Number: N64A/36 (Formerly sold as S64A-36)

Immunogen: Synthetic peptide amino acids 845-862 of human TRPC7

Swiss-Prot: Q9HCX4

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~100kDa.

Cellular Localization: Membrane

Scientific Background: Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (1). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (2).

References: 1. Numaga T., Wakamori M., and Mori Y. (2007) Handb Exp Pharmacol. 179: 143-151.2. Satoh S., et al. (2007) Mol Cell Biochem. 294(1-2): 205-215.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-343D-PCP
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-343D-PCP
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 57113
• Wirt: Mouse