Tunicamycin, CAS 11089-65-9

Autophagy inducer

Product Type: Inducer

CAS No.: 11089-65-9

MolecularFormula: C39H64N4O16

Molecular Weight: 844,95

Source: Isolated from Streptomyces lysosuperficus

Purity: >98% (HPLC) as a mixture of tunicamycin A, B, C and D

Solubility: Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).

Appearance: White solid.

Scientific Background: As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy.

References: 1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14.2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10.3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12.4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-397-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-397-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK