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UHRF1 antibody (HL2287)
UHRF1 antibody (HL2287)
Artikelnummer
GTX638342025-S-25
Verpackungseinheit
25 μl
Hersteller
GeneTex
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Clone Name: HL2287
Light Chain: Kappa
Application Note: WB: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 90
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Uniprot ID: Q96T88
Antigen Species: Human
Immunogen: Recombinant fragment of human UHRF1.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: ubiquitin like with PHD and ring finger domains 1
Light Chain: Kappa
Application Note: WB: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 90
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Uniprot ID: Q96T88
Antigen Species: Human
Immunogen: Recombinant fragment of human UHRF1.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: ubiquitin like with PHD and ring finger domains 1
| Artikelnummer | GTX638342025-S-25 |
|---|---|
| Hersteller | GeneTex |
| Hersteller Artikelnummer | GTX638342025-S-25 |
| Green Labware | Nein |
| Verpackungseinheit | 25 μl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus) |
| Klonalität | Monoclonal |
| Methode | Immunohistochemistry (paraffin), Western Blotting |
| Isotyp | IgG |
| Human Gene ID | 29128 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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