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Utrophin antibody (DRP3/20C5)
Utrophin antibody (DRP3/20C5)
Artikelnummer
GTX01977-500
Verpackungseinheit
500 μl
Hersteller
GeneTex
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Clone Name: DRP3/20C5
Application Note: IHC-Fr: 1:2–1:10. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 394
Specificity/Sensitivity: This antibody recognizes amino terminal domain of the human homolog of human dystrophin, utrophin.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.
Concentration:
Background: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot ID: P46939
Antigen Species: Human
Immunogen: Fusion protein containing the first 261 amino acids of the published DMDL gene sequence.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: utrophin
Application Note: IHC-Fr: 1:2–1:10. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 394
Specificity/Sensitivity: This antibody recognizes amino terminal domain of the human homolog of human dystrophin, utrophin.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.
Concentration:
Background: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot ID: P46939
Antigen Species: Human
Immunogen: Fusion protein containing the first 261 amino acids of the published DMDL gene sequence.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: utrophin
| Artikelnummer | GTX01977-500 |
|---|---|
| Hersteller | GeneTex |
| Hersteller Artikelnummer | GTX01977-500 |
| Green Labware | Nein |
| Verpackungseinheit | 500 μl |
| Mengeneinheit | STK |
| Reaktivität | Human, Rat (Rattus), Dog (Canine) |
| Klonalität | Monoclonal |
| Methode | Immunohistochemistry (frozen) |
| Isotyp | IgG1 |
| Human Gene ID | 7402 |
| Wirt | Mouse |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
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