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UVRAG Antibody: ATTO 594
Rabbit Anti-Human UVRAG Polyclonal
Artikelnummer
STRSPC-606D-A594
Verpackungseinheit
100 µg
Hersteller
Stressmarq Biosciences
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Target: UVRAG.
Conjugate: ATTO 594.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the mid-protein of human UVRAG.
Swiss-Prot: Q9P2Y5.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.
Cellular Localization: Endosome, Lysosome, Endoplasmic reticulum, Nucleus, Chromosome, Centromere.
Scientific Background: UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.
References: 1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45.4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Conjugate: ATTO 594.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the mid-protein of human UVRAG.
Swiss-Prot: Q9P2Y5.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.
Cellular Localization: Endosome, Lysosome, Endoplasmic reticulum, Nucleus, Chromosome, Centromere.
Scientific Background: UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.
References: 1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45.4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
| Artikelnummer | STRSPC-606D-A594 |
|---|---|
| Hersteller | Stressmarq Biosciences |
| Hersteller Artikelnummer | SPC-606D-A594 |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus) |
| Klonalität | Polyclonal |
| Methode | Immunofluorescence, Western Blotting, Immunocytochemistry |
| Human Gene ID | 7405 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
Laurent Haze
