VU0467154, CAS 1451993-15-9

M4 Receptor Agonist

Product Type: Inhibitor

CAS No.: 1451993-15-9

MolecularFormula: C17H15F3N4O3S2

Molecular Weight: 444,45

Source: Synthetic

Purity: >98% (HPLC)

Solubility: Soluble in DMSO

Appearance: Tan Solid

PubChem CID: PMC4324418

Scientific Background: Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.

References: 1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 - 942.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-184-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-184-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK