Wortmannin, CAS 19545-26-7

Autophagy inhibitor

Product Type: Inhibitor

CAS No.: 19545-26-7

MolecularFormula: C23H24O8

Molecular Weight: 428,44

Source: Synthetic

Purity: ≥98%

Solubility: Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).

Appearance: White to off-white solid.

PubChem CID: 312145

Scientific Background: Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.

References: 1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23.2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61.3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4.4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-392-1MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-392-1MG
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK