Formulation: A solid
Formal Name: N-(4,6-dimethyl-2-pyrimidinyl)-N′-[2-(trifluoromethyl)phenyl]-guanidine
Purity: ≥98%
Formula Markup: C14H14F3N5
Formula Weight: 309,3
Shelf life (days): 1460
CAS Number: 303094-67-9
Notes: ZINC69391 is an inhibitor of the protein-protein interaction between Rac1 and the Rho guanine nucleotide exchange factor TIAM1.{51743} It inhibits the interaction between Rac1 and TIAM1 in a cell-free assay when used at a concentration of 200 µM. ZINC69391 is also active against chloroquine-resistant and -susceptible strains of P. falciparum (IC50 = 17.56 and 12.56, respectively).{51746} It inhibits the proliferation of MDA-MB-231, F3II, and MCF-7 breast cancer cells (IC50s = 48, 61, and 31 µM, respectively).{51743} ZINC69391 (10 µM) induces cell cycle arrest at the G1 phase in MDA-MB-231 cells. It inhibits EGF-induced actin polymerization in, and the migration and invasion of, MDA-MB-231 and F3II cells when used at a concentration of 50 µM. In vivo, ZINC69391 (25 mg/kg per day) reduces the number of lung nodules in an F3II murine model of lung metastasis when administered at a dose of 25 mg/kg per day.
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