1-Palmitoyl-d3-2-hydroxy-sn-glycero-3-PC, CAS 2692624-19-2

Formulation: A solid

Formal Name: (7R)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphapentacosan-25,25,25-d3-1-aminium, inner salt, 4-oxide

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C24H47D3NO7P

Formula Weight: 498,7

Shelf life (days): 730

CAS Number: 2692624-19-2

Notes: 1-Palmitoyl-d3-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC (Item No. 10172) by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.{11139} It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 µM.{42919} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 µM.{42920} It increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 µM.{42921} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.{11693}

• Artikelnummer: CAY28229
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28229-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung