11β-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody

Formulation: 500 µl of peptide affinity-purified polyclonal antibody

Immunogen: Synthetic peptide from the N-terminal region of human 11β-HSD2

Shelf life (days): 1095

Notes: 11β-Hydroxysteroid Dehydrogenase (Type 2) (11β-HSD2) catalyzes the conversion of cortisol (hydrocortisone; Item No. 20739) to the inactive glucocorticoid cortisone (Item No. 30763), thereby protecting the mineralcorticoid receptor from glucocorticoid excess.{12000} It is primarily expressed in the kidneys, but has also been detected in the colon, salivary glands, and fetal tissues, including the placenta, and is localized to the endoplasmic reticulum.{12000,58670} Knockout of HSD11B2, the gene encoding 11β-HSD2, reduces fetal and placental growth as well as capillary development in mice.{58671} Loss-of-function mutations in HSD11B2 result in apparent mineralcorticoid excess (AME), an inborn error of metabolism characterized by hypertension, hypokalemia, and reduced plasma renin activity.{12000} Cayman's 11β-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes 11β-HSD2 at 44 kDa from mouse samples.

• Artikelnummer: CAY10004549-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10004549-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Wirt: Rabbit