12-keto Chenodeoxycholic Acid, CAS 2458-08-4

Formulation: A solid

Formal Name: (3α,5β,7α)-3,7-dihydroxy-12-oxo-cholan-24-oic acid

Purity: ≥95%

Formula Markup: C24H38O5

Formula Weight: 406,6

Shelf life (days): 1460

CAS Number: 2458-08-4

Notes: 12-keto Chenodeoxycholic acid (12-keto CDCA) is an intermediate in the semisynthetic synthesis of ursodeoxycholic acid (Item Nos. 31016 / 15121) and chenodeoxycholic acid (Item Nos. 10011286 / 35346) from the primary bile acid cholic acid (Item No. 20250).{69644,69645} 12-keto CDCA has been found in the gastric tissues of C57BL/6J mice, KM mice, Sprague-Dawley rats, New Zealand white rabbits, and JX black pigs.{69646} Fecal levels of 12-keto CDCA are increased in children with hepatic glycogen storage disease.{69647} The sodium salt of 12-keto CDCA, known as 12-monoketocholic acid (12-MKA), increases brain uptake of quinine (Item No. 23958), the analgesic effect of morphine in the hot plate test, and pentobarbital-induced sleeping time in rats when administered at a dose of 2 mg/kg.{69648} It also promotes nasal absorption of insulin and increases the duration of local anesthesia induced by lidocaine in rats.{69648},{59253}

• Artikelnummer: CAY30838-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30838-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK