13C28-Bongkrekic Acid

Formulation: A 5 µg/ml solution in methanol

Formal Name: (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-((carboxy-13C)methyl-13C)-6-(methoxy-13C)-2,5,17-tri(methyl-13C)docosa-2,4,8,10,14,18,20-heptaenedioic-1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22-13C22 acid

Purity: ≥98%

Formula Markup: [13C]28H38O7

Formula Weight: 514,4

Shelf life (days): 730

Notes: 13C28-Bongkrekic Acid is intended for use as an internal standard for the quantification of bongkrekic acid (Item No. 38230) by GC- or LC-MS. Bongkrekic acid is polyketide and bacterial toxin that has been found in B. gladioli.{30508,68268} It is an inhibitor of ADP/ATP translocase (AAT), a carrier protein that imports ADP into the mitochondrial matrix and exports ATP into the intermembrane space.{30508,68267} It prevents ADP import and inhibits mitochondrial respiration (Ki = 20 nM in isolated rat liver mitochondria).{68269,68270} Bongkrekic acid induces cell death in MCF-7 human breast cancer cells deprived of estradiol for six months (EC50 = 2.58 µM).{68271} It is toxic to mice (LD50s = 0.68-6.84 mg/kg, p.o.).{68272}

• Artikelnummer: CAY39454-1.2
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39454-1.2
• Verpackungseinheit: 1.2 ml
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung