2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt), CAS 99827-72-2

Formulation: A solution in water

Formal Name: 2′,3′-dideoxy-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥95%

Formula Markup: C10H12N5O11P3 • 4Na

Formula Weight: 563,1

Shelf life (days): 730

CAS Number: 99827-72-2

Notes: 2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2′,3′-dideoxyadenosine (ddA; Item No. 36662) and didanosine (ddI; Item No. 23715).{28262,28268,64902} It is formed from ddI via a 2',3'-dideoxyAMP intermediate by phosphoribosyl pyrophosphate synthase (PRS).{64902} It inhibits DNA polymerase isolated from mouse Ehrlich ascites tumor cells in the presence of ATP or GDP (Kis = 60 and 18 µM, respectively).{28263} 2',3'-Dideoxyadenosine-5'-O-triphosphate and other dideoxynucleoside 5'-triphosphates are commonly used to terminate chain extension by Taq polymerases in PCR assays.{28266}

• Artikelnummer: CAY38373
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38373-2.4
• Verpackungseinheit: 2.4 mg
• Mengeneinheit: STK
• Methode: Reinstoffe