2',3'-Dideoxycytidine-5'-O-triphosphate (sodium salt)

Formulation: A solution in water

Formal Name: 2′,3′-dideoxy-cytidine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥95%

Formula Markup: C9H12N3O12P3 • 4Na

Formula Weight: 539,1

Shelf life (days): 730

Notes: 2',3'-Dideoxycytidine-5'-O-triphosphate is an active metabolite of the reverse transcriptase inhibitor zalcitabine (Item No. 16019).{61905} It is an inhibitor of DNA polymerases β and γ (Kis = 1.32 and 0.034 µM, respectively, for the human enzymes).{66342} 2',3'-Dideoxycytidine-5'-O-triphosphate (1 mM) inhibits HIV-1 replication in isolated human erythrocytes.{66343} Intraperitoneal administration of 2',3'-dideoxycytidine-5'-O-triphosphate-loaded erythrocytes reduces spleen and lymph node weight, limits increases in IgG levels, and decreases mediastinal lymph node swelling in a mouse model of LP-BM5 leukemic retrovirus infection-induced immunodeficiency.{66343}

• Artikelnummer: CAY38374
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38374-2.3
• Verpackungseinheit: 2.3 mg
• Mengeneinheit: STK
• Methode: Reinstoffe