2'(3')-O-(N'-Methylanthraniloyl)guanosine-5'-O-diphosphate (sodium salt)

Formulation: A solution in water

Formal Name: 2′(or 3′)-[2-(methylamino)benzoate] guanosine 5′-(trihydrogen diphosphate), trisodium salt

Purity: ≥95% (mixture of isomers)

Formula Markup: C18H19N6O12P2 • 3Na

Formula Weight: 642,3

Shelf life (days): 730

Notes: 2'-O-(N'-Methylanthraniloyl)guanosine-5'-O-diphosphate (2’-MANT-GDP) and 3’-MANT-GDP are fluorescent GDP derivatives, which undergo spontaneous isomerization.{67344} 2’(3’)-MANT-GDP selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, AC6, and bovine lung soluble guanylyl cyclase (sGC; Kis = 430, 2,600, 510, 320, and 4,200 nM, respectively) over B. anthracis edema factor AC toxin, rat testis soluble AC (sAC), and B. pertussis AC toxin (Kis = 37, 48, and 60 µM, respectively). 2’(3’)-MANT-GDP has been used to quantify guanine nucleotide exchange of GTPases.{66402} A related derivative, 2'(3')-MANT-GTP (Item No. 38469), displays an emission maximum of 442 nm upon excitation at 350 nm.{67581}

• Artikelnummer: CAY38468
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38468-2.9
• Verpackungseinheit: 2.9 mg
• Mengeneinheit: STK
• Methode: Reinstoffe, Fluorescence