2′-C-β-Methylguanosine, CAS 374750-30-8

Formulation: A solid

Formal Name: 2′-C-methyl-guanosine

Purity: ≥95%

Formula Markup: C11H15N5O5

Formula Weight: 297,3

Shelf life (days): 1460

CAS Number: 374750-30-8

Notes: 2’-C-β-Methylguanosine is an active nucleoside metabolite of the antiviral prodrug BMS-986094.{65197} It inhibits replication in genotype 1b hepatitis C virus (HCV) replicon cells (EC50s = 5.2 and 3.2 µM in ELISA and luciferase assays, respectively).{65198} 2’-C-β-Methylguanosine also inhibits replication of the Zika virus clinical isolate ZIKVPE243 in infected human brain microvascular endothelial cells (HBMECs), SH-SY5Y cells, and Vero cells (EC50s = 0.88, 2.09, and 1.25 µM, respectively) but is toxic to mice infected with ZIKVPE243 at postnatal day 2 when administered at a dose of 25 mg/kg per day.{65199}

• Artikelnummer: CAY36548-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36548-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe