3′,5′-diOA-dC

Formulation: A solution in ethanol

Formal Name: 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-((oleoyloxy)methyl)tetrahydrofuran-3-yl oleate

Purity: ≥95%

Formula Markup: C45H77N3O6

Formula Weight: 756,1

Shelf life (days): 365

Notes: 3′,5′-diOA-dC is a ligand for the bacterial second messenger, cyclic dinucleotide, and STING agonist cyclic di-GMP (Item No. 17144) composed of oleic acid (Item Nos. 90260 / 24659) and deoxycytidine.{66521} It assembles with cyclic di-GMP to form supramolecular nanoparticles and has been used to deliver cyclic di-GMP in vitro and in vivo. Intravenous administration of nanoparticles composed of 3′,5′-diOA-dC and cyclic di-GMP decrease tumor weight and volume, increase the number of CD8+ T cells, neutrophils, and natural killer (NK) cells in the tumor microenvironment, and increase tumoral levels of TNF-α and IFN-γ in a B16/F10 murine melanoma model.

• Artikelnummer: CAY39087-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39087-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK