Product Type: Inhibitor
CAS No.: 5142-23-4
MolecularFormula: C6H7N5
Molecular Weight: 149,2
Source: Synthetic
Purity: ≥98%
Solubility: Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
Appearance: White solid.
PubChem CID: 1673
Scientific Background: 3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation.
References: 1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6.2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64.3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.