306-O12B, CAS 2566523-06-4

Formulation: A solution in methyl acetate

Formal Name: tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate

Purity: ≥95%

Formula Markup: C59H115N3O8S8

Formula Weight: 1251,1

Shelf life (days): 730

CAS Number: 2566523-06-4

Notes: 306-O12B is an ionizable cationic lipidoid.{69117} It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA targeting Angptl3 (sgAngptl3), the gene encoding angiopoietin-related protein 3, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum Angptl3 protein, LDL, and triglyceride levels.

• Artikelnummer: CAY37549-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37549-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe