39732

Formulation: A solution in ethanol

Formal Name: ((2-(pyrrolidin-1-yl)ethyl)azanediyl)bis(decane-1,2-diyl) dioctanoate

Purity: ≥95%

Formula Markup: C42H82N2O4

Formula Weight: 679,1

Shelf life (days): 365

Notes: 11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.{69765} LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet.

• Artikelnummer: CAY40747-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40747-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK