5-Azacytidine, CAS 320-67-2

DNA hypomethylation agent

Product Type: Inhibitor

CAS No.: 320-67-2

MolecularFormula: C8H12N4O5

Molecular Weight: 244,2

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble in 25 mg/ml DMSO or 12 mg/ml Water

Appearance: White Solid

PubChem CID: 9444

Scientific Background: DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.

References: 1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536.2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55.3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-345-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-345-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK