5-Ph-IAA, CAS 168649-23-8

Formulation: A solid

Formal Name: 5-phenyl-1H-indole-3-acetic acid

Purity: ≥95%

Formula Markup: C16H13NO2

Formula Weight: 251,3

Shelf life (days): 1460

CAS Number: 168649-23-8

Notes: 5-Ph-IAA is a phenylic substituted indole and ligand used for bump and hole, a technique used to study single protein isoforms when familial homology would interfere with other isoform-selective approaches.{65606,65607} It activates a bump-and-hole-modified protein, transport inhibitor response 1 (TIR1), which forms a PROTAC-associated complex that targets and degrades sister chromatid cohesion 1 (RAD21) and induces cell cycle arrest at the G2 or M phase in Arabidopsis when used at a concentration of 1 µM.{65607} Intraperitoneal administration of 5-Ph-IAA (1, 3, or 10 mg/kg per day) reduces tumor growth via the same process by targeting and degrading bromodomain-containing protein 4 (BRD4) in an HCT116 colorectal cancer xenograft mouse model.

• Artikelnummer: CAY38161-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38161-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe