8-bromo NAD+ (sodium salt), CAS 2022926-16-3

Formulation: A solid

Formal Name: 8-bromo-adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, monosodium salt

Purity: ≥95%

Formula Markup: C21H25BrN7O14P2 • Na

Formula Weight: 764,3

Shelf life (days): 730

CAS Number: 2022926-16-3

Notes: 8-bromo NAD+ is a prodrug form of the cyclic ADP-ribose (cADPR) inhibitor 8-bromo cADPR (Item No. 18442).{66400} It is converted to 8-bromo-cADPR by CD38. 8-bromo NAD+ (1 mM) prevents increases in intracellular calcium levels and chemotaxis induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in isolated mouse bone marrow-derived neutrophils. It also decreases LPS-induced nitrite production and TNF-α and IL-2 secretion in mouse primary microglial cells when used at a concentration of 100 µM.{66401}

• Artikelnummer: CAY38475
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38475-7.4
• Verpackungseinheit: 7.4 mg
• Mengeneinheit: STK
• Methode: Reinstoffe