α-Enolase Polyclonal Antibody

Formulation: 250 µg of protein A-purified polyclonal antibody

Immunogen: Full length recombinant human α-enolase

Shelf life (days): 1095

Notes: α-Enolase, also known as enolase 1, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.{42086} It is ubiquitously expressed in human tissues, including liver, spleen, kidney, and brain. In cells, α-enolase is primarily localized to the cytoplasm, however, an alternatively translated form localizes to the nucleus and lacks glycolytic enzyme activity.{42086,42087} α-Enolase also functions as a cell surface receptor for plasminogen on pathogens and activated immune cells, as an oxidative stress protein in endothelial cells, and as a chromatin binding partner to facilitate transcription.{42087,42088,42089} The ENO1 promoter contains a hypoxia-response element, allowing α-enolase to facilitate aerobic glycolysis and contribute to the Warburg effect in tumor cells.{42087} α-Enolase is overexpressed in multiple tumors, including glioma, neuroblastoma, pancreatic, prostate, and hepatocellular carcinomas. Its role as a plasminogen receptor facilitates extracellular matrix degradation and cancer invasion.{42089} α-Enolase is an autoantigen in asthma, Hashimoto's encephalopathy, and rheumatoid arthritis, and has been found in the serum of pediatric patients with juvenile idiopathic arthritis.{42090,42091,42092,36062} Cayman's α-Enolase Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes α-enolase at ~47 kDa from human samples.

• Artikelnummer: CAY20491-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20491-250
• Green Labware: Nein
• Verpackungseinheit: 1 ea (250 µg)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, ELISA, Immunohistochemistry
• Wirt: Rabbit