A83 01, CAS 909910-43-6

ALK kinase inhibitor

Product Type: Inhibitor

CAS No.: 909910-43-6

MolecularFormula: C25H19N5S

Molecular Weight: 421.5

Source: Synthetic

Purity: ≥98% (HPLC)

Solubility: Soluble to 50 mM in DMSO

Appearance: White to beige powder

PubChem CID: 16218924

Scientific Background: A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase. It blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 also inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7.

References: 1. Li W., et al. (2009) Stem Cell 4(1): 16–19. 2. Cherukuri P., et al. (2012). PloS One. 7(11): e50066.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-423-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-423-5MG
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK