AJ2-30, CAS 2700322-79-6

Formulation: A solid

Formal Name: 9-ethyl-N-(1-methyl-1H-benzimidazol-2-yl)-9H-carbazole-3-methanamin

Purity: ≥98%

Formula Markup: C23H22N4

Formula Weight: 354,5

Shelf life (days): 1460

CAS Number: 2700322-79-6

Notes: AJ2-30 is an inhibitor of the endolysosome transporter solute carrier family 15 member A4 (SLC15A4).{68740} It is selective for SLC15A4 over SLC15A3 at 5 µM. AJ2-30 reduces increases in IFN-α levels induced by the toll-like receptor 9 (TLR9) agonist CPG-2216 in primary human plasmacytoid dendritic cells (IC50 = 1.8 µM). It also inhibits NOD2 signaling mediated by the NOD2 ligand muramyl dipeptide (MDP; Item No. 30866) in a reporter assay using A549 cells expressing membrane-localized SLC15A4 (IC50 = 2.6 µM). AJ2-30 reduces increases in IFN-α and IL-6 induced by the TLR9 agonist CPG-2006 or the TLR7 agonist R-837 (imiquimod; Item No. 14956) in peripheral blood mononuclear cells (PBMCs) isolated from patients with systemic lupus erythematosus (SLE). It reduces IFN-α, IFN-β, and IFN-γ production induced by a CPG-2216-DOTAP complex in mice when administered at a dose of 50 mg/kg.

• Artikelnummer: CAY40667-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40667-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK