Formulation: A solution in ethanol
Formal Name: 2-hexyl-decanoic acid, 1,1'-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl] ester
Purity: ≥98%
Formula Markup: C48H95NO5
Formula Weight: 766,3
Shelf life (days): 365
CAS Number: 2036272-55-4
Notes: ALC-0315 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).{62365} Administration of severe acute respiratory coronavirus 2 (SARS-CoV-2) mRNA in ALC-0315-containing LNPs induces the production of IgG that binds to the SARS-CoV-2 receptor-binding domain (RBD) in rhesus macaques, with a boost in antigen-specific IgG geometric mean titers (GMT) seven and 14 days after a second dose. Formulations containing ALC-0315 have been used in the development of LNPs for the delivery of mRNA-based vaccines.