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ALK2 (ACVR1) (R206H), GST-Tag Recombinant
ALK2 (ACVR1) (R206H), GST-Tag Recombinant
Artikelnummer
BPS100714
Verpackungseinheit
10 µg
Hersteller
BPS Bioscience
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Encompassing Amino Acids: 147-509(end)
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: ALK2 (activin receptor-like kinase 2), also known as ACVR1 or activin A receptor type 1, is a bone morphogenic protein receptor involved in BMP (bone morphogenic protein) signal transduction. ALK2 forms complexes with BMPs, which then recruit proteins from the SMAD family (Mothers against decapentaplegic homolog). It participates in the development and regulation of the skeletal system, heart, brain and reproductive system. ALK2 dysfunction can lead to fibrodysplasia ossificans progressive (FOP), where the BMP/SMAD pathway is hyper-activated and mesenchymal stem cells differentiate along the osteogenic pathway and transform into bone all over the body. Mutations in ALK2 were also found in cancer, such as diffuse intrinsic pontine glioma (DIPG) and child brain cancer. ALK2 inhibitors have been studied in pre-clinical models of FOP and DIPG and showed great promise. Further studies into ALK2 will deepen our understanding of its functions, find new inhibitors and new therapeutic avenues for patients with ALK-linked cancer.
Description: Recombinant human ALK2 (Activin receptor-like kinase 2) encompassing amino acids 147-509 (end) and containing the clinically relevant mutation R206H. In this construct the N-terminal end of ALK2 is fused with GST. A short peptide linker placed between GST and PARP7 includes a thrombin site to facilitate removal of the GST portion. The recombinant protein was affinity purified.
Format: Aqueous buffer solution
Formulation: 20 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 2 mM GSH
Genbank: NM_001105.5
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Supplied As: Aqueous buffer solution.
Tags: C-terminal GST-tag
Uniprot: Q04771
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
Encompassing Amino Acids: 147-509(end)
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: ALK2 (activin receptor-like kinase 2), also known as ACVR1 or activin A receptor type 1, is a bone morphogenic protein receptor involved in BMP (bone morphogenic protein) signal transduction. ALK2 forms complexes with BMPs, which then recruit proteins from the SMAD family (Mothers against decapentaplegic homolog). It participates in the development and regulation of the skeletal system, heart, brain and reproductive system. ALK2 dysfunction can lead to fibrodysplasia ossificans progressive (FOP), where the BMP/SMAD pathway is hyper-activated and mesenchymal stem cells differentiate along the osteogenic pathway and transform into bone all over the body. Mutations in ALK2 were also found in cancer, such as diffuse intrinsic pontine glioma (DIPG) and child brain cancer. ALK2 inhibitors have been studied in pre-clinical models of FOP and DIPG and showed great promise. Further studies into ALK2 will deepen our understanding of its functions, find new inhibitors and new therapeutic avenues for patients with ALK-linked cancer.
Description: Recombinant human ALK2 (Activin receptor-like kinase 2) encompassing amino acids 147-509 (end) and containing the clinically relevant mutation R206H. In this construct the N-terminal end of ALK2 is fused with GST. A short peptide linker placed between GST and PARP7 includes a thrombin site to facilitate removal of the GST portion. The recombinant protein was affinity purified.
Format: Aqueous buffer solution
Formulation: 20 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 2 mM GSH
Genbank: NM_001105.5
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Supplied As: Aqueous buffer solution.
Tags: C-terminal GST-tag
Uniprot: Q04771
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
| Artikelnummer | BPS100714 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 100714 |
| Green Labware | Nein |
| Verpackungseinheit | 10 µg |
| Mengeneinheit | STK |
| Wirt | Human |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
