Formulation: A solution in methanol:water:formic acid
Formal Name: 2-propene-1-sulfinothioic acid, S-2-propen-1-yl ester
Purity: ≥95%
Formula Markup: C6H10OS2
Formula Weight: 162,3
Shelf life (days): 730
CAS Number: 539-86-6
Notes: Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities.{25626,36056,36054,36055} It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 µM, respectively.{25625} It shows antiparasitic activity against P. falciparum (IC50 = 5.2 µM) and T. b. brucei (IC50 = 13.8 µM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines.{36056} It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.
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