AMG 458, CAS 913376-83-7

Formulation: A solid

Formal Name: 2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Purity: ≥98%

Formula Markup: C30H29N5O5

Formula Weight: 539,6

Shelf life (days): 1460

CAS Number: 913376-83-7

Notes: AMG 458 is an inhibitor of c-Met (Kis = 1.2, 1.1, 2.2, 4.1, 0.5, and 4.5 nM for wild-type c-Met, c-MetV1092I, c-MetD1228H, c-MetM1250T, c-MetH1094R, and c-MetY1230H, respectively).{66383} It inhibits c-Met phosphorylation in PC3 and CT26 cells (IC50s = 60 and 120 nM, respectively). AMG 458 (30 and 100 mg/kg) reduces tumor volume in NIH3T3 and U87MG mouse xenograft models.

• Artikelnummer: CAY36213-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36213-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe