Aminopeptidase N/CD13 (C-Term) Rabbit Monoclonal Antibody

Formulation: 100 µl of protein A-affinity purified monoclonal antibody

Immunogen: Peptide from the C-terminal region of human aminopeptidase N

Clone Designation: RM403

Shelf life (days): 365

Notes: Aminopeptidase N, also known as cluster of differentiation 13 (CD13), is a zinc-dependent and membrane-bound ectopeptidase and type II membrane glycoprotein encoded by ANPEP in humans.{58316,58315} It is composed of a short N-terminal cytosolic domain, a membrane-spanning domain, and five extracellular domains, including a C-terminal catalytic domain.{58315,58317} It is ubiquitously expressed on cell membranes where it functions as a dimer to degrade peptides and proteins containing N-terminal neutral amino acids.{58315} Plasma levels of soluble aminopeptidase N are increased and positively correlated with tumor progression in patients with non-small cell lung cancer (NSCLC).{58316} ANPEP is overexpressed in psoriatic skin lesions, synovial fibroblasts isolated from patients with rheumatoid arthritis, and lymphocytes and peripheral blood mononuclear cells (PBMCs) isolated from patients with multiple sclerosis during acute exacerbation and chronic progression.{58315} Cayman’s Aminopeptidase N/CD13 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

• Artikelnummer: CAY32329
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 32329-100
• Green Labware: Nein
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG
• Wirt: Rabbit