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AMSH, His-tag Recombinant
AMSH, His-tag Recombinant
Artikelnummer
BPS81080
Verpackungseinheit
25 µg
Hersteller
BPS Bioscience
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Encompassing Amino Acids: full length
Applications: This enzyme cleaves K63-linked ubiquitin chains in vitro. Suggested Substrate: DiUbiquitin K63
Background: AMSH (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSH mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM.
Description: Human AMSH recombinant protein, full length, with His-tag, expressed in E. coli.
Format: Aqueous buffer solution
Storage Stability: Store at or below -80°C. Stable as supplied for up to 1 year when stored dessicated at -80°C.
Tags: His-tag
Uniprot: Q96FJ0
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. McCullough, J., et al. AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol, 2004. 166(4): p. 487-92.
2. McCullough, J., et al. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol, 2006. 16(2):p. 160-5.
Encompassing Amino Acids: full length
Applications: This enzyme cleaves K63-linked ubiquitin chains in vitro. Suggested Substrate: DiUbiquitin K63
Background: AMSH (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSH mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM.
Description: Human AMSH recombinant protein, full length, with His-tag, expressed in E. coli.
Format: Aqueous buffer solution
Storage Stability: Store at or below -80°C. Stable as supplied for up to 1 year when stored dessicated at -80°C.
Tags: His-tag
Uniprot: Q96FJ0
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. McCullough, J., et al. AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol, 2004. 166(4): p. 487-92.
2. McCullough, J., et al. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol, 2006. 16(2):p. 160-5.
| Artikelnummer | BPS81080 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 81080 |
| Green Labware | Nein |
| Verpackungseinheit | 25 µg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
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| MSDS (PDF) |
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Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
