Anti-CD22 (MB22-11)

Anti-CD22 [MB22-11], Recombinant, IgG2c kappa, Mouse

CloneID: MB22-11

Heavy Chain modification: Fc Silent™

Antigen Long Description: The original antibody was raised by immunizing a CD22-/- mice with mouse CD22.

Buffer Composition: PBS only.

Chimeric Use Statement: This is a reformatted mouse IgG2c Fc Silent™ antibody, based on the original mouse IgG2c format, created for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P35329

Specificity Statement: This antibody is specific for mouse CD22.

Application Notes (Clone): The ability of the original antibody to deplete B cell in vivo in mice was tested. It showed that is was able to deplete B cells NZB/W F1 and C57BL/6 mice. This antibody was used for an ELISA (Haas et al., 2010; PMID:20368280). The ability of this antibody to block the CD22 ligand was tested. It showed that the antibody inhibited CD22-mediated adhesion. This antibody was used in vivo on mice. Here it showed that the antibody was able to significantly reduce B cell numbers (Haas et al., 2006; PMID:16920943).

• Artikelnummer: ABAAb04589-4.3-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab04589-4.3-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Recombinant
• Methode: ELISA, In Vivo Assay, Inhibition
• Isotyp: IgG2c kappa
• Wirt: Mouse