Anti-Fibrillar alpha-syn (6E)

Anti-Fibrillar alpha-syn [6E], Recombinant, scFv fragment (His)

CloneID: 6E

Heavy Chain modification: ScFv

Antigen Long Description: The original antibody was isolated from a human Tomlinson I and J scFv antibody libraries by panning the library against fibrillar α-synuclein prepared as per the method given in PMID: 16984950.

Buffer Composition: PBS only.

Chimeric Use Statement: This is a reformatted human scFv antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P37840

Specificity Statement: This antibody recognizes the fibrillar morphological form of human alpha-synuclein. Alpha-synuclein is a small 140 amino acid presynaptic neuronal protein, a major component of Lewy bodies and a member of the synuclein family. Misfolding, abnormal accumulation, and secretion of α-Synuclein (α-Syn) are closely associated with synucleinopathies, including Parkinson’s disease (PD). α-syn is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, α-syn is found mainly at the tips of neurons in the specialized structures known as presynaptic terminals and has been shown to comprise up to ∼1% of total proteins in the neuronal cytosol. Recent evidence suggests that α-synuclein (α-syn) can contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS).

Application Notes (Clone): The binding of this antibody to fibrillar alpha-synuclein was confirmed using ELISA. This antibody is not capable of recognizing monomeric and oligomeric forms of alpha-synuclein (PMID: 16984950).

• Artikelnummer: ABAAb04615-30.11-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab04615-30.11-BT
• Verpackungseinheit: 500 μg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: ELISA, Functional Assay
• Isotyp: scFv fragment (His)