Anti-Her2/neu (HerG1M)

Anti-Her2/neu [HerG1M], Recombinant, IgG1-Fc Fusion, Human

CloneID: HerG1M

Antigen Long Description: The original antibody was selected from a humanized VH single domain antibody gene library by screening against Her2/neu antigen.

Buffer Composition: PBS only.

Chimeric Use Statement: This is a chimeric antibody, developed from the original camelid VHH antibody, specifically engineered for enhanced compatibility with existing reagents, assays, and techniques.

Uniprot Accession No.: P04626

Specificity Statement: This antibody is specific for human Her2/neu.

Application Notes (Clone): The binding specificity of this humanized single-domain antibody (sdAb; VHH) was tested in an ELISA. This antibody was used to generate an anti-Her2/neu and anti-human Ig bi-specific construct together with Ab04651 [C3]. The bi-specific construct was tested in vitro on BT474 breast cancer cells using a CCK8 assay and demonstrated a significant inhibitory effect on the growth of the breast cancer cells (approximately 50 times more effective than Herceptin). The bi-specific construct also exhibited a significantly prolonged stability in vivo in mice compared to the sdAb version of the antibody (CN110964113B).

• Artikelnummer: ABAAb04653-10.159-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab04653-10.159-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: ELISA, In Vivo Assay, Inhibition
• Isotyp: IgG1-Fc Fusion
• Wirt: Human