CloneID: 4E9
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing transgenic mice having human antibody genes with purified monkeypox virus A29L protein.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: V9NS06
Specificity Statement: This antibody binds the A29L protein of the monkeypox virus. Mpox is an infectious disease caused by the monkeypox virus which can be transmitted to humans through physical contact with someone who is infectious, with contaminated materials, or with infected animals. It can cause a painful rash or mucosal lesions which can last 2–4 weeks, enlarged lymph nodes and fever. Monkeypox mortality rates range from 0%-11% in the general population and are higher in young children. In Q3 of 2024, the WHO declared monkeypox
a Public Health Emergency of International Concern. This product serves as a powerful tool for related research efforts.
Application Notes (Clone): The original mouse IgG antibody binds monkeypox virus A29L protein with a binding affinity in the sub-nanomolar range. This antibody can be used as a capture or coating antibody in a double antibody sandwich ELISA in combination with 7B10 as a labeling or detection antibody. The sensitivity of detection for this antibody pair is reported to be 0.5ng/ml (CN116284349).
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