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Applications: This product is for research use only. It is not suitable for human diagnostic or therapeutic use.
Assay Conditions: The antibody acted as a PD-1 agonist when added to FcGR2B/TCR activator CHO cells co-cultured with PD-1/NFAT Jurkat cells, as indicated by PD-1-mediated inhibition of TCR activation (co-culture assay described in BPS Bioscience #78436). In addition, this anti-PD-1 antibody did not antagonize PD-1/PD-L1 binding since the TCR activation signal was still inhibited by PD-1/PD-L1 signaling in the presence of the antibody (co-culture assay described in BPS Bioscience #60535).
Description: Anti-PD-1 agonist antibody is a purified recombinant antibody which recognizes human PD1 antigen. This antibody has been functionally tested in two co-culture assays.
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Purification: Protein A affinity purification from HEK293 cells
Purity: ≥90%
Storage Stability: At least 12 months at -80°C.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)