Anti-PD-L1-Fab Avi-Tag, Biotin-Labeled

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Encompassing Amino Acids: Heavy Chain: 1-210; Light Chain: 1-214(end)

Applications: Useful as an antagonist to block PD-L1 signaling and binding to PD-1 in biochemical assays.

Assay Conditions: Anti-PD-L1-Biotin (BPS Bioscience #11032) was titrated from 0 to 50 nM with a 2-fold dilution series in presence of 100 nM PD-L1-FLAG (BPS Bioscience #71183) and incubated for 1 hour at RT. Binding was detected with Anti-FLAG-Eu and Streptavidin-APC.

Description: PD-L1 Neutralizing Antibody FAB fragment, recombinant humanized monoclonal, recognizing the extracellular domain of human PD-L1 and blocking the binding of PD-L1 to PD-1. This antibody FAB has been shown to cross-react with mouse PD-L1. No other species have been tested.

Format: Aqueous buffer solution

Formulation: 8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol.

Host Cell Line: HEK293

Purification: Protein A affinity chromatography from HEK293 supernatants.

Storage Stability: Stable for at least 12 months at -80°C. Protect from light.

Supplied As: Aqueous buffer solution.

Tags: Heavy Chain: N-terminal Avi-tag

Uniprot: Q9NZQ7

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Vernon-Wilson, E.F. et al., Eur. J. Immunol. 2000; 30(8): 2130-2137. 2. Majeti, R. et al., Cell. 2009; 138(2): 286- 299.

• Artikelnummer: BPS11032
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 11032
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Klonalität: Monoclonal
• Isotyp: IgG1
• Wirt: Human