Anti-sST2 (67186-15)

Anti-sST2 [67186-15], Recombinant, IgG kappa, Rabbit

CloneID: 67186-15

Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with recombinant human sST2 protein.

Buffer Composition: PBS only.

Uniprot Accession No.: Q01638

Specificity Statement: This antibody binds soluble form of human ST2 which is a member of the interleukin (IL)-1 receptor family. IL-33 is the ligand for ST2, which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues. In in vitro and in vivo models, ST2L transduces the effects of IL-33, while excess sST2 or abnormalities in ST2 signaling leads to cardiac hypertrophy, fibrosis, and ventricular dysfunction. Circulating soluble ST2 concentration is believed to reflect cardiovascular stress and fibrosis. ST2 is a new cardiovascular biomarker for assessing acute heart failure and predicting the outcome of chronic heart failure.

Application Notes (Clone): HRP labelled version of this antibody was used as a detection antibody in combination with 67186-6 as capture antibody for the development of a double-antibody sandwich ELISA for detection of soluble ST2 in blood samples (CN105259353).

• Artikelnummer: ABAAb04665-23.0-BT
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: Ab04665-23.0-BT
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: ELISA
• Isotyp: IgG kappa
• Wirt: Rabbit