English
Anti-ST2L (ST2M51)
Anti-ST2L [ST2M51], Recombinant, IgG2 kappa, Human
Artikelnummer
ABAAb04661-11.0-BT
Verpackungseinheit
1 mg
Hersteller
Absolute Antibody
Verfügbarkeit:
wird geladen...
Preis wird geladen...
CloneID: ST2M51
Antigen Long Description: The original antibody was isolated from a human Fab phage display library by panning against hST2L ECD (residues 18–328)-Fc fusion protein. Later on the antibody was converted to a human IgG2 format.
Buffer Composition: PBS only.
Uniprot Accession No.: Q01638
Specificity Statement: This antibody specifically binds an epitope in domain III of the human ST2L and cross reacts with cynomolgus monkey ST2L. ST2L a transmembrane receptor that belongs to the IL-1 receptor family which is expressed on the cell surface of a wide variety of immune cells including T cell, NK/NKT cells, basophils, eosinophils, mast cells and the newly-described non-B/non-T innate lymphoid type 2 cells, nuocytes, and natural helper cells. ST2L expression is also inducible on dendritic cells (DCs), macrophages, and neutrophils. ST2L is able to downregulate the responsiveness of Toll-like Receptors TLR2, TLR4, and TLR9, but also induce type 2 cytokine release via activation by its ligand IL-33 and association with accessory protein IL-1RAcP.
Application Notes (Clone): This antibody is not capable of blocking the interaction between IL-33 and ST2L. This antibody was capable of recognizing recombinant human ST2L extracellular domain (ST2L-ECD) using an ELISA assay (PMID: 27294560). The original human IgG2 chimeric version of the antibody binds human and cynomolgus monkey ST2L with a binding affinity of 38 pM and 76 pM respectively (US9090694). This antibody was capable of binding ST2L expressed by LAD2 mast cells in a flow cytometric assay. This antibody was reported to block the IL-33 induced activation of NF-kB in a dose dependent manner. This antibody also blocked IL-1RAcP from binding to the ST2L/IL-33 complex. It can also inhibit cytokine secretion by human basophilic cell line KU812 (PMID: 27294560).
Antigen Long Description: The original antibody was isolated from a human Fab phage display library by panning against hST2L ECD (residues 18–328)-Fc fusion protein. Later on the antibody was converted to a human IgG2 format.
Buffer Composition: PBS only.
Uniprot Accession No.: Q01638
Specificity Statement: This antibody specifically binds an epitope in domain III of the human ST2L and cross reacts with cynomolgus monkey ST2L. ST2L a transmembrane receptor that belongs to the IL-1 receptor family which is expressed on the cell surface of a wide variety of immune cells including T cell, NK/NKT cells, basophils, eosinophils, mast cells and the newly-described non-B/non-T innate lymphoid type 2 cells, nuocytes, and natural helper cells. ST2L expression is also inducible on dendritic cells (DCs), macrophages, and neutrophils. ST2L is able to downregulate the responsiveness of Toll-like Receptors TLR2, TLR4, and TLR9, but also induce type 2 cytokine release via activation by its ligand IL-33 and association with accessory protein IL-1RAcP.
Application Notes (Clone): This antibody is not capable of blocking the interaction between IL-33 and ST2L. This antibody was capable of recognizing recombinant human ST2L extracellular domain (ST2L-ECD) using an ELISA assay (PMID: 27294560). The original human IgG2 chimeric version of the antibody binds human and cynomolgus monkey ST2L with a binding affinity of 38 pM and 76 pM respectively (US9090694). This antibody was capable of binding ST2L expressed by LAD2 mast cells in a flow cytometric assay. This antibody was reported to block the IL-33 induced activation of NF-kB in a dose dependent manner. This antibody also blocked IL-1RAcP from binding to the ST2L/IL-33 complex. It can also inhibit cytokine secretion by human basophilic cell line KU812 (PMID: 27294560).
| Artikelnummer | ABAAb04661-11.0-BT |
|---|---|
| Hersteller | Absolute Antibody |
| Hersteller Artikelnummer | Ab04661-11.0-BT |
| Verpackungseinheit | 1 mg |
| Mengeneinheit | STK |
| Reaktivität | Human, Cynomolgus Monkey (Primate) |
| Klonalität | Recombinant |
| Methode | ELISA, Flow Cytometry, Functional Assay |
| Isotyp | IgG2 kappa |
| Wirt | Human |
| Produktinformation (PDF) |
|
| MSDS (PDF) | Download |
Verwandte Artikel
Markieren Sie die Artikel, um Sie dem Warenkorb hinzuzufügen oder
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
