Antrodin A, CAS 656830-24-9

Antrodin A, CAS 656830-24-9
Artikelnummer
CAY36094-10
Verpackungseinheit
10 mg
Hersteller
Cayman Chemical

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Formulation: A solution in ethanol

Formal Name: 3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-4-(2-methylpropyl)-2,5-furandione

Purity: ≥95%

Formula Markup: C19H22O4

Formula Weight: 314,4

Shelf life (days): 730

CAS Number: 656830-24-9

Notes: Antrodin A is a microbial metabolite originally found in A. camphorata that has antiviral and hepatoprotective activities.{68600,68601,68602} It is an inhibitor of hepatitis C virus (HCV) protease (IC50 = 0.9 µg/ml).{68600} Antrodin A reduces cytotoxicity in Vero cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 (IC50s = 5.8 and 5.5 µg/ml, respectively) and has additive effects on HSV-induced cytotoxicity when combined with the antiviral guanosine analog acyclovir (Item No. 14160).{68601} It decreases viral plaque formation in Vero cells infected with HSV-1 or HSV-2 in a concentration-dependent manner. Antrodin A (200 mg/kg per day) inhibits alcohol-induced increases in serum triglyceride levels and decreases in serum HDL levels in a mouse model of alcoholic fatty liver disease (ALD).{68602} It also prevents alcohol-induced increases in hepatic lipid accumulation and the activity of serum alanine transaminase (ALT) and aspartate aminotransferase (AST), as well as decreases in the activity of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase and in the levels of glutathione (GSH) in isolated mouse liver in the same model.
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Artikelnummer CAY36094-10
Hersteller Cayman Chemical
Hersteller Artikelnummer 36094-10
Green Labware Nein
Verpackungseinheit 10 mg
Mengeneinheit STK
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