AP20187, CAS 195514-80-8

Formulation: A solid

Formal Name: 2-piperidinecarboxylic acid, (2S,2′S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2,2′-[[2-[(dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester

Purity: ≥95%

Formula Markup: C82H107N5O20

Formula Weight: 1482,8

Shelf life (days): 1460

CAS Number: 195514-80-8

Notes: AP20187 is a chemical inducer of dimerization (CID) for FK506 binding protein (FKBP) fusion proteins.{67124} It increases expression of the genes encoding DNA damage-inducible transcript 3 (Ddit3) and growth arrest and DNA damage-inducible protein 34 (Gadd34) in primary mouse neonatal glial cells when used at a concentration of 0.1 nM.{67123} It increases apoptosis induced by adenoviral vectors expressing conditional caspase-1 (Ad-G/iCasp1) in LNCaP and PC3 human prostate, as well as TRAMP-C2 and TRAMP-C2G murine prostate, cancer cells in a concentration-dependent manner.{67124} AP20187 (2 mg/kg), when used in combination with Ad-G/iCasp1, induces apoptosis and reduces tumor volume in a TRAMP-C2 murine prostate cancer model. It induces apoptosis in p16Ink4a-positive senescent cells and increases lifespan in ATTAC transgenic mice expressing FKBP-Casp8 and GFP when administered at a dose of 2 µg/g twice per week.{67122} AP20187 delays tumorigenesis and reduces glomerulosclerosis and kidney dysfunction in the same mouse model.

• Artikelnummer: CAY36808-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36808-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe