APS6-45, CAS 2188236-41-9

Formulation: A solid

Formal Name: 4-[4-[[[[2-fluoro-5-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C23H16F8N4O3

Formula Weight: 548,4

Shelf life (days): 1460

CAS Number: 2188236-41-9

Notes: APS6-45 is an inhibitor of RETM918T and a derivative of sorafenib (Item No. 10009644 / 35612).{51345} It selectively binds to RETM918T over Eph tyrosine kinase receptor A8 (EphA8), p38δ, JNK2, and c-Src (Kds = 28, 410, 940, 1,500, and 1,700 nM, respectively), as well as a panel of over 60 kinases at 10 µM, but also binds to cyclin-dependent kinase 14 (Cdk14), MAP4K4, and protein tyrosine kinase 5 (PTK5; Kds = 55, 130, and 140 nM, respectively). It inhibits TT medullary thyroid carcinoma cell colony formation when used at a concentration of 30 nM. APS6-45 (10 mg/kg per day) decreases tumor volume in a TT mouse xenograft model. It increases survival to adulthood in Drosophila expressing the lethal RetM955T mutation in a concentration-dependent manner. APS6-45 (100 µM) prevents the development of a rough-eye phenotype induced by RetM955T in Drosophila.

• Artikelnummer: CAY38417-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38417-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe