AXIN1 antibody, C-term

Application Note: IHC-P: 3-5μg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 96

Positive Control: The peptide used to generate this antibody is available for purchase (GTX89836-PEP).

Specificity/Sensitivity: This antibody is expected to recognise both reported isoforms.

Form: Liquid

Buffer (with preservative): TBS, 0.5% BSA, 0.02% Sodium azide.

Concentration: 0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot ID: O15169

Antigen Species: Human

Immunogen: Peptide with sequence C-FEEKIIGKVEKVD, from the C Terminus of the protein sequence according to NP_003493.1; NP_851393.1.

Purification: Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation: Unconjugated

Full Name: axin 1

• Artikelnummer: GTX89836-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX89836-100
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG
• Human Gene ID: 8312
• Wirt: Goat