AXIN2 Polyclonal Antibody, Rabbit

Abbreviation: AXIN2

Target Synonym: AXIN2;AXIL;ODCRCS;axin-2

Conjugation: Unconjugated

UNIProt ID: Q9Y2T1

Background: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human AXIN2

Dilution: WB 1:500-1:2000

• Artikelnummer: ELSE-AB-93196-200
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-93196-200
• Green Labware: Nein
• Verpackungseinheit: 200 µl
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit