AZ 304, CAS 942507-42-8

Formulation: A solid

Formal Name: 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-benzamide

Purity: ≥95%

Formula Markup: C27H25N5O2

Formula Weight: 451,5

Shelf life (days): 1460

CAS Number: 942507-42-8

Notes: AZ 304 is an inhibitor of B-RAF and B-RAF containing a valine-to-glutamate substitution at position 600 (B-RAFV600E; IC50s= 79 and 38 nM, respectively).{65859} It is selective for B-RAF and B-RAFV600E over MAP3K7 and C-terminal Src kinase (CSK) (IC50s = 6,400 and 7,050 nM, respectively), as well as insulin-like growth factor 1 receptor (IGF-1R), EGFR, cyclin-dependent kinase 2 (Cdk2), Cdk4, JAK2, and c-Src (IC50s = >10,000 nM for all), but also inhibits p38 MAPK, CSF-1 receptor tyrosine kinase (FMS), and C-RAF (IC50s = 6, 35, and 79 nM, respectively). AZ 304 (10 and 100 µM) reduces the proliferation of RKO, HT-29, DiFi, and Caco-2 colon cancer cells. In vivo, AZ 304 (10 mg/kg twice daily), alone or in combination with the anti-EGFR antibody cetuximab, reduces tumor volume in RKO and Caco-2 colon cancer mouse xenograft models.

• Artikelnummer: CAY37580-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37580-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK