Azido-PEG6-alcohol, CAS 86770-69-6

Product Description: Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azido-PEG6-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C12H25N3O6

References: [1]Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292./[2]Loredana Vesci, et al. HDAC INHIBITORS-BASED ANTIBODY DRUG CONJUGATES (ADCs) AND USE IN THERAPY. WO2018178060A1.

CAS Number: 86770-69-6

Molecular Weight: 307.34

Compound Purity: 98.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• Artikelnummer: MEXHY-130537-1G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130537-1G
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK