b-AP15 (NSC-687852), CAS 1009817-63-3

DUB inhibitor

Product Type: Inhibitor

CAS No.: 1009817-63-3

MolecularFormula: C22H17N3O6

Molecular Weight: 419,4

Source: Synthetic

Purity: >98%

Solubility: Soluble in 35 mg/ml DMSO

Appearance: Pale Yellow Solid

PubChem CID: 5351435

Scientific Background: Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

References: 1. D'Arcy P., et al. (2011) Nature Medicine 17: 1636.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-339-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-339-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK