Bafilomycin A1, CAS 88899-55-2

Autophagy inhibitor

Product Type: Inhibitor

CAS No.: 88899-55-2

MolecularFormula: C35H58O9

Molecular Weight: 622,84

Source: Synthetic

Purity: >98% HPLC; NMR (Conforms)

Solubility: May be dissolved in DMSO (50mg/mL)

Appearance: White powder to colorless film.

PubChem CID: 6436223

Scientific Background: Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.

References: 1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212.2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16.3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-391-100UG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-391-100UG
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK