Bassoon Antibody: APC

Rabbit Anti-Human Bassoon Polyclonal

Target: Bassoon.

Conjugate: APC .

Product Type: Polyclonal.

Immunogen: NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein.

Swiss-Prot: Q9UPA5.

Purification: Protein A Purified.

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide.

Concentration: 1 mg/ml.

Specificity: Detects ~420kDa. Multiple isoforms can be detected.

Cellular Localization: Cytoplasm, Cell Junction, Synapse.

Scientific Background: Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).

References: 1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 1008–1029.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSPC-198D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SPC-198D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Human Gene ID: 8927
• Wirt: Rabbit